GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs4263408 | 1 | rs7661070 | chr4:39724365 | RPL9 | chr4:39455747-39460568:- | -0.45 | -7.39 | 9.36E-13 | Plasma amyloid beta peptide concentrations (ABx-40) |
| BLCA | cis | rs4699052 | 1 | rs7661702 | chr4:104140129 | MANBA | chr4:103552644-103682151:- | 0.26 | 4.23 | 2.92E-5 | Testicular germ cell tumor |
| BLCA | cis | rs11723261 | 1 | rs7665727 | chr4:277057 | ZNF718 | chr4:53272-156488:+ | 0.34 | 4.66 | 4.33E-6 | Immune response to smallpox vaccine (IL-6) |
| BLCA | cis | rs11723261 | 1 | rs7674560 | chr4:263319 | ZNF718 | chr4:53272-156488:+ | 0.29 | 4.2 | 3.27E-5 | Immune response to smallpox vaccine (IL-6) |
| BLCA | cis | rs6547741 | 1 | rs76784350 | chr2:27764278 | C2orf16 | chr2:27799389-27805588:+ | 0.23 | 3.92 | 0.000103 | Oral cavity cancer |
| BLCA | cis | rs6951245 | 1 | rs76804143 | chr7:1082021 | ZFAND2A | chr7:1192544-1199855:- | -0.37 | -4.41 | 1.33E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs80285556 | 1 | rs76812330 | chr19:50531860 | SIGLEC16 | chr19:50472912-50479075:+ | 0.51 | 4.97 | 1.03E-6 | antipsychotic drug dosage in schizophrenia or schizoaffective disorder |
| BLCA | cis | rs798766 | 1 | rs7682402 | chr4:1743343 | FAM53A | chr4:1641609-1685854:- | -0.31 | -4.5 | 8.9E-6 | Urinary bladder cancer;Bladder cancer |
| BLCA | cis | rs6951245 | 1 | rs76833820 | chr7:1070278 | ZFAND2A | chr7:1192544-1199855:- | -0.37 | -4.31 | 2.12E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs11723261 | 1 | rs7686546 | chr4:240614 | ZNF718 | chr4:53272-156488:+ | 0.34 | 4.54 | 7.4E-6 | Immune response to smallpox vaccine (IL-6) |
| BLCA | cis | rs4263408 | 1 | rs7687557 | chr4:39769260 | RPL9 | chr4:39455747-39460568:- | -0.42 | -7.14 | 4.68E-12 | Plasma amyloid beta peptide concentrations (ABx-40) |
| BLCA | cis | rs76878669 | 1 | rs76878669 | chr11:66092567 | CTSW | chr11:65647284-65651212:+ | 0.25 | 3.89 | 0.000117 | Educational attainment (years of education) |
| BLCA | cis | rs78153629 | 1 | rs76994419 | chr15:40714150 | C15orf23 | chr15:40674922-40686488:+ | 0.34 | 5.63 | 3.51E-8 | Heschl's gyrus morphology |
| BLCA | cis | rs7705093 | 1 | rs7705093 | chr5:96290647 | ERAP2 | chr5:96211644-96255398:+ | 0.98 | 27.18 | 2.03E-91 | Birdshot chorioretinopathy |
| BLCA | cis | rs7714584 | 1 | rs7705542 | chr5:150228318 | LOC134466 | chr5:150310000-150326146:- | 0.43 | 5.35 | 1.52E-7 | Crohn's disease |